Aberrant Phenotype and Function of Myeloid Dendritic Cells in Systemic Lupus Erythematosus. Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus. Pan Q, Gong L, Xiao H, Feng Y, Li L, Deng Z, et al. The Contribution of Macrophages to Systemic Lupus Erythematosus. T Follicular Helper (Tfh) Cells in Lupus: Activation and Involvement in SLE Pathogenesis. Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us. Scientists at the Oklahoma Medical Research Foundation (OMRF. The treatment of people with systemic lupus by stem cells has already yielded very positive results, some of which are mentioned herein. Stem cell therapy accomplishes both objectives. Immunomodulation inefficacy mesenchymal stem cells modification systemic lupus erythematosus transplantation.Ĭopyright © 2021 Li, Guo, Pan, Chen, Chen, Liu and Pan. Such a treatment would, in fact, constitute the only truly effective therapy for systemic lupus. However, their safety and protective effects in patients with SLE still need to be confirmed by further experimental and clinical evidence. We propose various MSC modification methods that may be beneficial in enhancing the immunosuppression of MSCs in SLE. This review summarizes the status of MSC therapy in refractory SLE treatment and potential reasons for the ineffectiveness of MSC therapy from three perspectives. Therefore, the therapeutic effects of MSCs should be further confirmed. However, MSC therapy is also reported ineffective in some patients with SLE, which may be related to MSC- or patient-derived factors. This therapy can improve the signs and symptoms of refractory SLE by promoting the proliferation of Th2 and Treg cells and inhibiting the activity of Th1, Th17, and B cells, etc. Recently, mesenchymal stem cell (MSC) therapy for autoimmune diseases, particularly SLE, has gained increasing attention. Therefore, effective and low side-effect therapies for SLE are lacking. Although previous studies have demonstrated that SLE is related to the imbalance of cells in the immune system, including B cells, T cells, and dendritic cells, etc., the mechanisms underlying SLE pathogenesis remain unclear. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
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